[Wine] The file is not marked as an executable??? How to?

[QuicheLoraine]

I get the error, "The file 'media/cdrom/autoplay.exe' is not marked as an executable"...and won't let me mark it as an executable in the permissions, "permission denied" when attempting to run the startup for Adobe CS4 Design Premium. Ubuntu Lucid LTS, BTW. I have tried to install from Wine both from the menu and the terminal per the information I found on the wiki, but no go. Anyone? Very Frustrating. :?