What Wine version are you using? If not 1.3.34 or 1.3.35 please upgrade. NWN2 Platinum starts and runs fine here with Wine-1.3.35. I have only the following native dlls in use: msvcr80.dll dxdiagn.dll d3dx9_30.dll Native devenum.dll is not needed(?). I have a Nvidia 250 card with latest proprietary driver (290.10).