[Wine] works on live Knoppix, but not on Ubuntu / Kubuntu installs

[jaranov]

I have an industrial app I'm trying to get working on wine.   
It runs ok using with the Knoppix 6.4.4 live cd [using 1.0.1.]   Does not work on Kubuntu or Ubuntu, with either wine 1.2 or after I downgraded to wine version to 1.0.1. 
1) Any idea why?  
2) Is there an "installed" distro that's very similar to  Knoppix 6.4.4. ? 
Thanks.