Can wine be used in Mac OS X (UNIX) with X11 installed?

[Mark]

Can wine be used in Mac OS X (UNIX) with or without X11 installed?

I use wine in Red Hat Linux 9 and would also like to use wine in Mac OS 
X to also run some Windows applications in Mac OS X.

Since Microsoft bought Connectix Virtual PC for Mac OS X and has already 
trashed the product some, I am looking for an alternative to use.  There 
may be more Virtual PC users seeking the same later.