[Wine] Apps slow down after several minutes

[faceplant]

A problem I have with most applications I've tried is after several minutes, they will slow down to a crawl, becoming unusable. The program I'm mainly interested in is Painkiller (http://www.gamespot.com/pc/action/painkiller/index.html). It runs beautifully at first, and I can usually get through a level, but after that, it slows down or even stops. Is this an issue in Wine or could this be resolved by playing with the configuration or something? Does this happen to anyone else?