[Wine] Diablo II: Interesting sound issue in 1.3

[Mysticete]

[Running Ubuntu 11.10 and Wine 1.3, ALSA sound, 24" iMac hardware]

Sound works perfectly in Diablo II without any customization... the first time.  No sound during gameplay after re-opening the application, and yet it continues to work fine for startup and in-game movies.  The only fixes I've found are to either run in desktop emulation mode (which is certainly not ideal) or to un-install and re-install wine (ditto.)  Any ideas for what's going on here?