[Wine] How to get started

[Newbie1]

40 years using every thing from Mainframe to Atari but I can not figure out how to Run a DOS/Windows program with Wine.  I have Knoppix 6.4.3 and I have found something called Wine Configurator but I have no idea what I'm configuring, my program that I want to run or the Knoppix desktop?  Because I am completely lost, can someone give me key-stroke by key-stroke details on how to run a DOS/Windows program?